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Friday, July 24, 2020 | History

4 edition of use of SCID mice in the investigation of human autoimmune disease found in the catalog.

use of SCID mice in the investigation of human autoimmune disease

by Peter C. Taylor

  • 2 Want to read
  • 37 Currently reading

Published by R.G. Landes in Austin .
Written in English

    Subjects:
  • Autoimmune diseases -- Animal models.,
  • Mice -- Diseases.,
  • Mice as laboratory animals.,
  • Autoimmune Diseases -- immunology.,
  • Immune System -- pathology.,
  • Mice, SCID.,
  • Chimera.

  • Edition Notes

    Includes bibliographical references and index.

    StatementPeter C. Taylor.
    SeriesMolecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)
    Classifications
    LC ClassificationsRC600 .T39 1994
    The Physical Object
    Pagination132 p. :
    Number of Pages132
    ID Numbers
    Open LibraryOL1102420M
    ISBN 101570591636
    LC Control Number94027365

      The immune system protects humans from threats such as, for example, disease-causing bacteria, and cancer as well. Yet if the system malfunctions, it can attack the body it is supposed to . Inflammatory bowel disease (IBD) is an inflammation of all or part of the human gastrointestinal (GI) tract. The most common forms of IBD are ulcerative colitis, which affects the colon, and Crohn's disease, .

    SCID mice: (mīs), Abbreviation for severe combined immunodeficient mice.   The recent discovery of a protein fragment capable of causing diabetes in mice has spurred researchers to propose a new hypothesis about the cause of diabetes and autoimmunity in .

      In contrast, hu-SCID mice derived from allergic and non-allergic donors had intense allergic lung inflammation and mucus over production illustrating that AAI-containing seed meal feeding Author: R Lee, D Reiner, A Maczó, N Bakos, É Gelencsér, Tjv Higgins, MM Epstein. NOD scid mice are immunodeficient mice with a diabetes-susceptible Non-Obese Diabetic (NOD) background for diabetes and obesity research. We use cookies to improve your browsing experience, .


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Use of SCID mice in the investigation of human autoimmune disease by Peter C. Taylor Download PDF EPUB FB2

Use of SCID mice in the investigation of human autoimmune disease. Austin: R.G. Landes, (OCoLC) Online version: Taylor, Peter C. Use of SCID mice in the investigation of human autoimmune disease.

Austin: R.G. Landes, (OCoLC) Document Type: Book. Mice with severe combined immunodeficiency (SCIDs) are often used in the research of human disease. Human immune cells are used to develop human lymphoid organs within these immunodeficient mice. Control of human thyroid autoantibody production in SCID mice.

Clin Exp Immunol. Mar; 91 (3)– [PMC free article] Reininger L, Radaszkiewicz T, Kosco M, Melchers F, Rolink AG.

Cited by:   / The Use of the Severe Combined Immunodeficient Mouse and the Athymic “Nude” Mouse as Models for the Study of Human Autoimmune Thyroid Disease. In: Clinical Immunology and Cited by: Splenic engraftment of human CEM T-lymphoblastoid cells was four-fold greater in NOD/LtSz-scid mice than in the C.B/Sz-scid mice.

Although C.B/Sz-scid mice exhibit robust NK cell activity, this. An example of the utility of Hu-SRC-SCID mice for infectious disease experiments was the study of Salmonella enteric serovar Thyphi infect S.

Typhi is highly adapted to humans and fails to Cited by: SCID mice are routinely used as model organisms for research into the basic biology of the immune system, cell transplantation strategies, and the effects of disease on mammalian have.

Peter C. Taylor has written: 'The use of SCID mice in the investigation of human autoimmune disease' -- subject(s): Animal models, Autoimmune diseases, Chimera, Diseases, Immune system, Immunology.

MODELS OF LYMPHOID AND MYELOID RECONSTRUCTION IN SCID MICE Can autoimmune diseases be induced in severe combined immunodeficient (SCID) mice.

A.O. Vladutiu Dept.s'. of PatholCited by: 4. We have been employing two mouse models for the study of human thyroid xenografts from patients with autoimmune thyroid disease (AITD).

The first mouse strain is that of the athymic Cited by: As SCID mice age, a variable percentage become 'leaky' from spontaneous development of functional T- and B-lymphocytes; Autosomal recessive, single nucleotide polymorphism with Prkdc gene on.

SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

Questions (29). Mice can teach us about human disease Scientists understand what fewer than one-fifth of human genes do; probing mice can help fill the gaps While humans and mice look and act very differently, 85 to 90.

Glomerular immune deposits (human IgG, mouse C3) were detected in % of SCID mice with human DNA specific antibodies and in a third of the human/mouse chimeras.

Immunodeficient mouse models, particularly severe combined immunodeficient (Prkdc scid and Rag1 null) mice, are very useful models for immunology, infectious disease, cancer, stem.

Crohn's Disease (CD) is a chronic inflammatory bowel disease (IBD) that can affect any portion of the gastrointestinal tract and can cause significant morbidity. A variety of animal models of both acute and Cited by: There are many rodent models of autoimmune diabetes that have been used to study the pathogenesis of human type 1 diabetes (T1D), including the non-obese diabetic (NOD) mouse, the biobreeding (BB) Cited by: Buy SCID Disease Model Mice Research on FREE SHIPPING on qualified orders.

Many events and requirements of the developmental program of human hematopoietic stem cells have not yet been discovered. A major impediment has been the lack of an appropriate Cited by:   INTRODUCTION. The humanized mice (hu-mice) model is commonly reconstituted with human blood-derived CD34 + stem cells using immune compromised mice such as SCID (Bosma et Cited by: 1.

Abstract. The objective of this study was to develop a human lupus model. To this end we have established and compared two models: (1) severe combined immunodeficient (SCID) mice Cited by: SCID mouse: [ mows ] a small rodent, various species of which are used in laboratory experiments.

1. a small loose body. 2. a computer pointing device. joint mouse a movable fragment of synovial .Several new immunodeficient mouse models for human cell engraftment have recently been introduced that include the Rag-/-γc-/- NOD/SCID, NOD/SCIDγc-/- and NOD/SCIDβ2m-/- strains.

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